By Deepak Thassu, Michel Deleers, Yashwant Vishnupant Pathak
With the arrival of analytical options and features to degree particle sizes in nanometer levels, there was great curiosity within the use of nanoparticles for extra effective equipment of drug supply. Nanoparticulate Drug supply structures addresses the clinical methodologies, formula, processing, functions, fresh traits, and rising applied sciences within the learn of nanoparticulate drug supply structures (NPDDS). It widely covers purposes of NPDDS? together with lipid nanoparticles for dermal functions nanocarriers for the remedy of restenosis and for ocular, important apprehensive method, and gastrointestinal functions. It additionally explores its use as an adjuvant for vaccine improvement.
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Additional resources for Nanoparticulate Drug Delivery Systems
12. Dingler A, Gohla S. Production of solid–lipid nanoparticles (SLN): scaling up feasibilities. J Microencapsul 2002; 19:11. 13. Gasco MR. Method for producing solid–lipid microspheres having narrow size distribution. US Patent 5,250,236, 1993. 14. Mehnert W, Mader K. Solid–lipid nanocapsules production, characterization and applications. Adv Drug Deliv Rev 2001; 47:165. 15. Muller RH, Mader K, Gohla S. Solid–lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art.
Physicochemical investigations on solid–lipid nanoparticles and on oil loaded solid–lipid nanoparticles: a nuclear magnetic resonance and electron spin resonance study. Pharm Res 2003; 20:1274. 3. Maestrell F, Mura P, Alonso MJ. Formulation and characterization of triclosan sub-micron emulsions and nanocapsules. J Microencapsul 2004; 21:857. 4. Lochmann D, Vogel V, Weyermann J, et al. Physicochemical characterization of protamine-phosphorothioate nanoparticles. J Microencapsul 2004; 21:625. 5. Geze A, Putaux JL, Choisnard L, Jehan P, Wouessidjewe D.
Moreover, the mechanism of release is attributable to a novel constrained diffusion mechanism provided by the precise geometry of the nanopore membrane itself, and no moving parts such as pistons are required. The drugs can likely be loaded into the device reservoir in a range of physical states, including solutions, crystalline, or micronized suspensions. Flexibility with respect to the physical form of encapsulated drugs provides options to substantially increase the loaded dose and duration of the therapy, as well as promoting approaches to increase stability of proteins, which are intrinsically unstable in an aqueous solution at body temperature (124–126).
Nanoparticulate Drug Delivery Systems by Deepak Thassu, Michel Deleers, Yashwant Vishnupant Pathak