By Charlotte Auerbach
This ebook is meant for the senior undergraduate (Honours pupil) in genetics, and for the postgraduate who desires a survey of the full box or info on a distinct zone inside of it. for you to cater for readers with such diversified specifications, i've got made the checklist of references strangely huge for a textbook. It contains classical papers in addition to very contemporary ones (to the top of 1974); stories in addition to really expert articles; trouble-free expositions from medical American in addition to hugely technical papers from journals on genetics and molecular biology. In components of lively examine, i've got given choice to the most recent references, so that it will lead the reader to prior ones. as well as the references on the finish of every bankruptcy, a bibliography on the finish of the ebook lists suitable books and basic reports. except the 1st bankruptcy, the publication isn't written as a heritage of mutation learn; yet all through i've got attempted to stress the continuity of the issues, suggestions and ideas. The reader will locate many examples of this. Muller's as soon as recognized after which nearly forgotten category of genes through their motion has now been given biochemical fact via reports of gene motion in vitro. the matter of even if mutations can come up in non-replicating genomes is likely one of the oldest in mutation learn; but an unequivocal answer was once received only in the near past with bacteriophage.
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Extra info for Mutation research: Problems, results and perspectives
A molecular mechanism was found to account for the delayed appearance of some mutations, but it could not explain instabilities that replicated as such. These have remained an intriguing problem. The application of kinetic data and of the target concept to UV and chemical mutagens met with partial success but was soon found to be subject to severe limitations. In general, it may be said of this period that its great achievement was the formulation of a biochemical or 'molecular' theory of mutation which was as impressive as the biophysical target theory formulated 20 years earlier.
Genes and Mutations' (1951), Cold Spring Harbor Symp. Quant. Bioi. 16. 21. Henning, U. and Yanofsky C. (1962), 'Amino acid replacements associated with reversion and recombination within the A gene',Proc. Nat. Acad. Sci. A. 18,1497-1504. 22. M. G. (1970), 'The intercistronic divide: Translation of an intercistronic region in the histidine operon of Salmonella typhimurium', Nature 226, 908-911. 23. lr. A. (1972), 'Visualization of RNA synthesis on chromosomes', Int. Rev. Cytol. 33, 1-25. CHAPTER TWO Classification of mutational changes at the chromosomal level If mutation in the widest sense is defined as a sudden heritable change, the term covers many disparate phenomena, only some of which will be considered in this book.
1928), " 'The measurement of gene mutation rate in Drosophila, its high variability and its dependence upon temperature', Genetics 13,279-357. 10. (1934), 'The experimental production of mutations', Bioi. Rev. 9,411-457. 11. W. ', Actualites scientifiques et industrielles 812. 12. Goldschmidt, R. ', Experientia 2, 250-256. 13. J. (1954), 'The Gene', Science 120,811-819. 14. H. (1959), 'The accurate estimation of chromatid breakage, and its relevance to a new interpretation of chromatid aberrations induced by ionizing radiations', Proc.
Mutation research: Problems, results and perspectives by Charlotte Auerbach