By Isaac Ghebre-Selassie
content material: Manufacture of center pellets via balling / Lucy S.C. Wan --
coaching of micropellets through spray congealing / A. Atilla Hincal, H. Suheyla Kas --
Cryopelletization / Axel Knoch --
Coating of multiparticulates utilizing polymeric options: formula and technique concerns / Klaus Lehmann --
Coating of multiparticulates utilizing molten fabrics: formula and approach issues / David M. Jones, Phillip J. Percel --
Suspensions and dispersible dosage types of multiparticulates / Roland Bodmeier, Ornlaksana Paeratakul --
Multiparticulate encapsulation apparatus and procedure / Donald ok. Lightfoot --
Compaction of multiparticulate oral dosage types / Metin Celik --
Key components within the improvement of modified-release pellets / Stuart C. Porter, Isaac Ghebre-Sellassie --
Mechanisms of free up from lined pellets / Jennifer B. Dressman ... [et al.] --
Biopharmaceutical features of multiparticulates / Johannes Kramer, Henning Blume --
In vivo habit of multiparticulate as opposed to single-unit dose formulations / George A. Digenis. (cont) tablet shell composition and production / Ronnie Millender --
Packaging of multiparticulate dosage varieties: fabrics and gear / K.S. Murthy, Franz Reiterer, Jurgen Wendt --
advertising issues for multiparticulate drug supply platforms / Roland Daumesnil.
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Extra info for Multiparticulate oral drug delivery
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REFERENCES 1. R. Bodmeier and O. Paeratakul, Spherical agglomerates of water-insoluble drugs, J. Pharm. Sci. 78(11):964 (1989). 2. European Patent EP 0 081 913 (1985). 3. German Patent DE 37 11 169 (1988). 4. C. G. Wilson and N. Washington, Assessment of disintegration and dissolution of dosage forms in vivo using gamma scintigraphy, Drug Dev. Ind. Pharm. 14(2-3): 211 (1988). 5. N. Washington, C. G. Wilson, J. L. Greaves, S. Norman, J. M. Peach, and K. Pugh, A gamma scintigraphic study of gastric coating by Expidet, tablet and liquid formulations, Int.
Moreover, with the larger spheres, single units can also be manufactured in a very simple way. These can be filled in dispensing systems or in conventional blister packages or bottles. So many attractive, innovative, and unique dosage forms can be realized. In combination with Cryodry, freeze-drying equipment of Buse Gase, which uses only liquid nitrogen as coolant, in contrast to conventional lyophilizers that require fluorocarbons, the Cryopel technology meets all environmental requirements. Alfatec-Pharma GmbH is investigating matrix formulations that can be dried conventionally in fluidized-bed dryers to minimize energy costs where thermal stress is not a problem.
Multiparticulate oral drug delivery by Isaac Ghebre-Selassie