By Vitaliy V. Khutoryanskiy
Mucoadhesion outlined as attachment of man-made or common fabrics to mucosal tissues has been broadly exploited in pharmaceutical types. This multi-author booklet offers an up to date account of present learn on mucoadhesive fabrics and drug supply platforms. The introductory part describes the constitution and body structure of assorted mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). this is often by means of chapters at the a variety of equipment used to review mucoadhesion and to characterise mucoadhesive homes of varied dosage forms. �Read more...
summary: Mucoadhesion outlined as attachment of artificial or normal fabrics to mucosal tissues has been broadly exploited in pharmaceutical types. This multi-author publication offers an updated account of present study on mucoadhesive fabrics and drug supply platforms. The introductory part describes the constitution and body structure of varied mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). this is often by means of chapters at the quite a few equipment used to review mucoadhesion and to characterise mucoadhesive homes of assorted dosage varieties
Read or Download Mucoadhesive Materials and Drug Delivery Systems PDF
Similar pharmacy books
This worthwhile reference provides a finished overview of the fundamental tools for characterizing bioadhesive fabrics and enhancing motor vehicle concentrating on and uptake-offering percentages for reformulating present compounds to create new prescribed drugs at decrease improvement charges. Evaluates the original provider features of bioadhesive polymers and their energy to augment localization of added brokers, neighborhood bioavailability, and drug absorption and delivery!
This authoritative Fourth variation summarizes the advances of the earlier decade in regards to the constitution, mechanism, and biochemistry of cytochrome P450 enzymes, with adequate insurance of prior paintings to make every one bankruptcy a finished evaluation of the sphere. 13 chapters are divided into unique volumes, the 1st protecting the basics of cytochrome P450 biochemistry, in addition to the microbial, plant, and bug platforms, and the second one completely targeting mammalian structures.
Layout and Manufacture of Pharmaceutical capsules bargains genuine international recommendations and results of formula and processing demanding situations of pharmaceutical capsules. This publication contains a number of functional examples regarding genuine formulations which were confirmed and advertised and covers vital info within the parts of balance, dissolution, bioavailibity and processing.
Now totally up-to-date for a moment variation, the Oxford guide of scientific Pharmacy continues to be the indispensible advisor to medical pharmacy, supplying all of the details wanted for training and scholar pharmacists. offering convenient functional counsel in a quick-reference, bullet-point layout, it's going to provide the data and self belief you must supply a medical pharmacy provider.
- Process Validation in Manufacturing of Biopharmaceuticals: Guidelines, Current Practices, and Industrial Case Studies
- Introduction to pharmacology
- Nanotechnology and Drug Delivery, Volume One: Nanoplatforms in Drug Delivery
- BMA Concise Guide to Medicine & Drugs
- Naturstoffchemie: Eine Einführung
Extra info for Mucoadhesive Materials and Drug Delivery Systems
The fact that a thin layer forms faster is in agreement with the general adsorption behaviour of polymers, whereby the smaller and faster diffusing molecules have an advantage compared to larger and slowly diffusing molecules. The latter, however, may have higher surface afﬁnity and, therefore, with time replaces initially adsorbed proteins . The constant exchange of material with the bulk of the salivary ﬁlms keeps the pellicle regenerated and maintains its integrity . In addition to secretory components, salivary ﬁlms contain a number of highly variable admixtures, such as residual food particles, as well as carbohydrates and proteins of bacterial origin.
The tyrosine, proline and glutamine residues are conﬁned to the carboxyl terminal that spans two-thirds of the statherin molecule. These three amino acids account for 75% of the residues present in this segment, resulting in a 310 helix structure being featured in the C-terminal between the residues Pro36 and Phe43. In the central part, a polyproline type II helix is formed in the region between residues Gly19 and Gln35 [103,104], thus forming a characteristic kink in the statherin that makes it resemble a short-footed Latin letter ‘L’.
The lowest estimate is, therefore, at least two orders of magnitude lower than the friction measured on dry or water-lubricated hydrophobic contacts. 02 , with somewhat similar results being found for the salivary MG1 and MG2 fractions [211,212]. Berg et al.  performed AFM colloidal probe experiments using a smooth silica colloidal sphere sliding on a silica substrate lubricated by a 10% Human Whole Saliva (HWS) solution. 03, which is very similar to the above values. However, when biological surfaces are used, for example the tongue surface, the values of the friction coefﬁcient are usually higher.
Mucoadhesive Materials and Drug Delivery Systems by Vitaliy V. Khutoryanskiy