Mucoadhesive Materials and Drug Delivery Systems by Vitaliy V. Khutoryanskiy PDF

By Vitaliy V. Khutoryanskiy

ISBN-10: 1118794370

ISBN-13: 9781118794371

ISBN-10: 1119941431

ISBN-13: 9781119941439

ISBN-10: 8320146151

ISBN-13: 9788320146158

Mucoadhesion outlined as attachment of man-made or common fabrics to mucosal tissues has been broadly exploited in pharmaceutical types. This multi-author booklet offers an up to date account of present learn on mucoadhesive fabrics and drug supply platforms. The introductory part describes the constitution and body structure of assorted mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). Read more...

summary: Mucoadhesion outlined as attachment of artificial or normal fabrics to mucosal tissues has been broadly exploited in pharmaceutical types. This multi-author publication offers an updated account of present study on mucoadhesive fabrics and drug supply platforms. The introductory part describes the constitution and body structure of varied mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). this is often by means of chapters at the quite a few equipment used to review mucoadhesion and to characterise mucoadhesive homes of assorted dosage varieties

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Extra info for Mucoadhesive Materials and Drug Delivery Systems

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The fact that a thin layer forms faster is in agreement with the general adsorption behaviour of polymers, whereby the smaller and faster diffusing molecules have an advantage compared to larger and slowly diffusing molecules. The latter, however, may have higher surface affinity and, therefore, with time replaces initially adsorbed proteins [164]. The constant exchange of material with the bulk of the salivary films keeps the pellicle regenerated and maintains its integrity [165]. In addition to secretory components, salivary films contain a number of highly variable admixtures, such as residual food particles, as well as carbohydrates and proteins of bacterial origin.

The tyrosine, proline and glutamine residues are confined to the carboxyl terminal that spans two-thirds of the statherin molecule. These three amino acids account for 75% of the residues present in this segment, resulting in a 310 helix structure being featured in the C-terminal between the residues Pro36 and Phe43. In the central part, a polyproline type II helix is formed in the region between residues Gly19 and Gln35 [103,104], thus forming a characteristic kink in the statherin that makes it resemble a short-footed Latin letter ‘L’.

The lowest estimate is, therefore, at least two orders of magnitude lower than the friction measured on dry or water-lubricated hydrophobic contacts. 02 [210], with somewhat similar results being found for the salivary MG1 and MG2 fractions [211,212]. Berg et al. [203] performed AFM colloidal probe experiments using a smooth silica colloidal sphere sliding on a silica substrate lubricated by a 10% Human Whole Saliva (HWS) solution. 03, which is very similar to the above values. However, when biological surfaces are used, for example the tongue surface, the values of the friction coefficient are usually higher.

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Mucoadhesive Materials and Drug Delivery Systems by Vitaliy V. Khutoryanskiy


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