Read e-book online MHC Molecules: Expression, Assembly and Function PDF

By Robert G. Urban Ph.D., Roman M. Chicz Ph.D. (auth.)

ISBN-10: 1468464620

ISBN-13: 9781468464627

ISBN-10: 1468464647

ISBN-13: 9781468464641

Show description

Read Online or Download MHC Molecules: Expression, Assembly and Function PDF

Similar nonfiction_12 books

New PDF release: Wars of the Iroquois: A Study in Intertribal Trade Relations

George T. Hunt’s vintage 1940 research of the Iroquois through the heart and overdue 17th century provides struggle due to depletion of traditional assets within the Iroquois place of birth and tribal efforts to imagine the function of middlemen within the fur exchange among the Indians to the west and the Europeans.

Read e-book online Transactions on Large-Scale Data- and Knowledge-Centered PDF

The LNCS magazine Transactions on Large-Scale facts- and Knowledge-Centered structures specializes in information administration, wisdom discovery, and information processing, that are center and scorching subject matters in computing device technology. because the Nineties, the net has develop into the most motive force at the back of software improvement in all domain names.

Additional info for MHC Molecules: Expression, Assembly and Function

Example text

RFXI-5, hXBP-I, c-fos, NF-Yas a few examples). Presum· ably, the H I histone protein (large blue protein) participates in this process by masking these sites on the inactive, assembled HLA-DRA nucleosome. The feasibility of this mechanism is supported by the position of all of the relevant cis·elements on one face of the nucleosome. (B) In the transcriptionally active HLA-DRA pro· moter, the relevant cis-elements are now occu· pied (note factors bound to each cis-element). The nonhistone protein HMG II Y (small olive spheres) is required for this transition.

Finally, it is important to note that, although the class II promoter cis-acting elements are highly conserved, there are small variations in the nucleotide sequence of elements in the different genes as well as between alleles of a particular gene. These variations have an influence on transcription factor binding, as well as on transcriptional activity of the promoters. Thus, nucleotide variations in factor binding 27 28 MHC Molecules: Expression, Assembly and Function sites may contribute to differential expression of both distinct and allelic class II promoters.

Map of the human MHC. Immunol Today 1991; 12:443-446. 4. Schwiebert LM, Schleimer RP, Ono SJ. The effect of the glucocorticoid dexamethasone on human class II MHC gene expression: evidence for isotype-specificity. Cell Immunol 1995; 165:12-19. 4a. Tanaka K, Yoshioka T, Bierberich et al. The role of the MHC class I antigens in tumor growth and metastasis. Ann Rev Immunol 1988; 6:359-380. 4b. Bottazzo GS, Dean BM, McNally JM et al. In site characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis.

Download PDF sample

MHC Molecules: Expression, Assembly and Function by Robert G. Urban Ph.D., Roman M. Chicz Ph.D. (auth.)


by John
4.2

Rated 4.07 of 5 – based on 38 votes