Get Intestinal Polyposis Syndromes: Diagnosis and Management PDF

By Lisa A. Boardman

ISBN-10: 3319281011

ISBN-13: 9783319281018

ISBN-10: 3319281038

ISBN-13: 9783319281032

This publication offers a finished, state-of-the paintings overview of intestinal polyposis syndromes. The booklet experiences the main up to date scientific, administration, and genetic information about the regularly evolving colorectal situation that manifests as a polyposis situation. It presents a reference for clinicians and researchers in realizing the complexity of intestinal polyposis and the significance of using a number of modalities for the analysis, administration and regulate of those stipulations. It additionally offers an outline of what may still alert a care supplier to the potential of a polyposis syndrome.

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Sample text

Expanded extracolonic tumor spectrum in MUTYH-associated polyposis. Gastroenterology. 2009;137:1976–85. 052. 36. Lipton L, Halford SE, Johnson V, Novelli MR, Jones A, Cummings C, et al. Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. Cancer Res. 2003;63:7595–9. 37. Aretz S, Tricarico R, Papi L, Spier I, Pin E, Horpaopan S, et al. Tyr179Cys and p. Gly396Asp by founder events. Eur J Hum Genet. 2014;22:923–9. 309. 38. Jones S, Lambert S, Williams GT, Best JM, Sampson JR, Cheadle JP.

MUTYH Heterozygotes As genetic testing for MUTYH has entered the algorithm for germline testing, either through cancer-specific genetic testing or via next-generation sequencing panels of hereditary cancer genes, this has led to the identification of monoallelic carriers of MUTYH mutations. The risk of CRC to MUTYH carriers was initially studied in parents of patients with biallelic MUTYH mutations and was estimated to be approximately twofold the general population incidence [27]. However, a more recent 2 MUTYH-Associated Polyposis 31 study of 2,332 patients with monoallelic MUTYH mutations found that the risk to carriers was dependent upon the family history of CRC.

Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 2000;342(26):1946–52. Epub 2000/06/30. 24. Lynch PM, Ayers GD, Hawk E, Richmond E, Eagle C, Woloj M, et al. The safety and efficacy of celecoxib in children with familial adenomatous polyposis. Am J Gastroenterol. 2010;105(6):1437–43. Epub 2010/03/18. 25. Sturgeon D, Herline AJ, Wise PE. Do NSAIDs suppress polyps in MUTYH-associated polyposis?

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Intestinal Polyposis Syndromes: Diagnosis and Management by Lisa A. Boardman


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