Inhibitors of Protein Kinases and Protein Phosphates by Lorenzo A. Pinna, Patricia T.W. Cohen PDF

By Lorenzo A. Pinna, Patricia T.W. Cohen

ISBN-10: 3540212426

ISBN-13: 9783540212423

The goals of this volume are to spotlight the great pharmacological strength of protein kinase and protein phosphatase inhibitors, to supply a radical assessment of the main amazing achievements within the box and to demonstrate how helpful those experiences might be for the development of either uncomplicated wisdom on organic legislation and deregulation and for the scientific therapy of a large spectrum of illnesses. This goal is attained by means of contributions of chief investigators within the box, who address the problem from assorted angles.

Show description

Read Online or Download Inhibitors of Protein Kinases and Protein Phosphates PDF

Best pharmacy books

Download e-book for kindle: Bioadhesive drug delivery systems: fundamentals, novel by Edith Mathiowitz, Donald E. Chickering III, Claus-Michael

This beneficial reference offers a accomplished evaluation of the fundamental tools for characterizing bioadhesive fabrics and bettering automobile focusing on and uptake-offering probabilities for reformulating latest compounds to create new prescription drugs at reduce improvement expenses. Evaluates the original service features of bioadhesive polymers and their energy to reinforce localization of brought brokers, neighborhood bioavailability, and drug absorption and delivery!

Cytochrome P450: Structure, Mechanism, and Biochemistry - download pdf or read online

This authoritative Fourth version summarizes the advances of the previous decade in regards to the constitution, mechanism, and biochemistry of cytochrome P450 enzymes, with enough assurance of previous paintings to make each one bankruptcy a complete overview of the sector. 13 chapters are divided into distinct volumes, the 1st protecting the basics of cytochrome P450 biochemistry, in addition to the microbial, plant, and bug structures, and the second one solely concentrating on mammalian structures.

Reynir Eyjolfsson's Design and Manufacture of Pharmaceutical Tablets PDF

Layout and Manufacture of Pharmaceutical drugs deals genuine international strategies and results of formula and processing demanding situations of pharmaceutical pills. This publication contains various functional examples regarding genuine formulations which have been proven and advertised and covers very important info within the parts of balance, dissolution, bioavailibity and processing.

Philip Wiffen, Marc Mitchell, Melanie Snelling, Nicola's Oxford Handbook of Clinical Pharmacy PDF

Now absolutely up to date for a moment variation, the Oxford instruction manual of medical Pharmacy continues to be the indispensible advisor to scientific pharmacy, offering all of the info wanted for practicing and pupil pharmacists. featuring convenient functional counsel in a quick-reference, bullet-point structure, it's going to provide the information and self belief you must offer a medical pharmacy provider.

Extra info for Inhibitors of Protein Kinases and Protein Phosphates

Sample text

J Med Chem 41:2252–60 Ando S, Tsujimura K, et al (1993) Phosphorylation of synthetic vimentin peptides by cdc2 kinase. Biochem Biophys Res Commun 195:837–43 Ando S, Ikuhara T, et al (1997) Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5. J Biochem [Tokyo] 122:409–14 Beaulieu PL, Cameron DR, et al (1999) Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements.

2 CDKs and GSK-3 as Kinase Screening Targets . . . . . . . . . Kinase Purification and Assay . . . . . . . . . . . . . Pharmacological Inhibitors of CDKs and GSK-3 . . . . . . . . 2 . . . . . . 5 Paullones as CDK and GSK-3 Inhibitors. . . . . . . . Discovery of Paullones . . . . . . . . . . . . . Molecular Mechanism of Interaction of Paullones with Kinases— Structure/Activity Relationship Studies . . . . . . . . Selectivity of Paullones .

Nat Struct Biol 8:37–41 Pellicena P, Stowell KR, et al (1998) Enhanced phosphorylation of Src family kinase substrates containing SH2 domain binding sites. J Biol Chem 273:15325–8 Pinna LA, Ruzzene M (1996) How do protein kinases recognize their substrates? Biochim Biophys Acta 1314:191–225 Pluskey S, Wandless TJ, et al (1995) Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem 270:2897–900 Profit AA, Lee TR, et al (1999) Bivalent inhibitors of protein tyrosine kinases.

Download PDF sample

Inhibitors of Protein Kinases and Protein Phosphates by Lorenzo A. Pinna, Patricia T.W. Cohen

by Kevin

Rated 4.20 of 5 – based on 41 votes