By Claude Weil
Ten years have elapsed because the book in 1978 of Vol. forty nine of the instruction manual of Experimental Pharmacology , a toOO-page survey of the information then on hand on Ergot Alkaloids and comparable Compounds. A ebook released in 1979 awarded the in formation on this kind of compounds, particularly co-dergocrine (Hydergine@), as extracted from the guide and up-to-date to take the newest advancements into consideration . Co-dergocrine had on the time been out there for 30 years and had given upward thrust to over 2000 papers, in order that one may have felt justified in considering that its clinical heritage had nearly come to an finish. It has now develop into seen that this type of view may were large of the mark. examine at the pharmacology and scientific pharmacology of co-dergocrine has remained as lively as ever. The ensuing obsolescence of the 1979 publication made worthy the instruction of the current model. Like its predecessor, it truly is meant as a list of findings and evidence instead of a piece facing their interpretation.
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Additional info for Hydergine®: Pharmacologic and Clinical Facts
2 Ilg/ kg a minute of co-dergocrine infused into the cerebral artery of the anesthetized dog lowered the blood pressure by only 12 mmHg, whereas intravenous infusion of the same dose lowered it by 23 mmHg.
Whereas a number of ergot derivatives counteract behavioral depression induced in mice by reserpine, dihydroergokryptine is virtually inactive in this respect . The effect of co-dergocrine on reserpine-induced PGO waves in the EEG has been described in section 1 c of this chapter. 8 mg/kg subcutaneous or intravenous co-dergocrine, protection from electroconvulsive shock was noted insofar as, instead of microscopic changes indicative of "capillary anemia" in control animals, there was dilatation of capillary vessels in the cerebral cortex .
The reduction in the number of PGO waves by co-dergocrine was accompanied by a reversal of the high-frequency, low-amplitude pattern seen in the cortical electroencephalogram [120, 552]. d) Effects on Cholinergic Neurotransmission Co-dergocrine has been found to have low affinity or none at all to central betaadrenergic, histaminergic, or cholinergic (muscarinic) receptors [75, 99, 296]. In spite of the compound's lack of affinity to cholinergic receptors, 3 mg/kg oral co-dergocrine daily for 4 weeks increased the activity of the enzyme choline acetyltransferase (ChAT) in the hippocampus and striatum of old rats (26-36 months of age), thus making up for the age-related decrease in ChAT activity; no such effect was seen in adult rats (11-12 months of age), and the activity of the enzyme acetylcholine esterase (AChE) was influenced neither in old nor in adult rats .
Hydergine®: Pharmacologic and Clinical Facts by Claude Weil