Download e-book for iPad: Hepatic De Novo Lipogenesis and Regulation of Metabolism by James M. Ntambi

By James M. Ntambi

ISBN-10: 3319250639

ISBN-13: 9783319250632

ISBN-10: 3319250655

ISBN-13: 9783319250656

The liver is the most important stable very important organ in mammals that helps different organ within the physique in a few part. This publication synthesizes all of the basic and proper metabolic details that one must evaluate to appreciate the complicated and various position of the liver in metabolism.

With the present epidemic of metabolic ailments, it really is of instant significance to appreciate the contribution of the liver in wellbeing and fitness and its position within the improvement of impaired metabolic law. This publication covers the various experiences that experience unmasked vital roles that proteins expressed within the liver play within the improvement of or defense from metabolic diseases.

One of the most important metabolic features of the liver is to hold out de novo lipogenesis, that is the metabolic pathway that enables the conversion of extra carbohydrates into fatty acids. the method of de novo lipogenesis is roofed extensive inside of this quantity. The e-book is a crucial contribution to the giant literature and ongoing learn on liver function.

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Extra resources for Hepatic De Novo Lipogenesis and Regulation of Metabolism

Example text

1 Dysregulation of DNL in Metabolic Syndromes and Cancer Dysregulated Lipogenesis in Metabolic Syndromes Dysregulated DNL processes are commonly observed in metabolic syndromes, including insulin resistance, non-alcoholic fatty liver disease and obesity (Ameer et al. 2014). Insulin resistance is a complex metabolic disorder in which cells fail to respond to the normal actions of insulin and that precedes the development of type 2 diabetes. The mechanisms of pathogenesis of insulin resistance involve ectopic lipid metabolites, activation of the unfolded protein response (UPR) pathway, and innate immune pathways (Samuel and Shulman 2012).

A better understanding of the regulation of DNL in specific pathological condition and identify disease-specific regulators of DNL will lead to more effective therapeutic avenue to correct abnormal DNL process. References Abdelmalek MF, Diehl AM (2007) Nonalcoholic fatty liver disease as a complication of insulin resistance. Med Clin North Am 91(6):1125–1149 Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ (1997) Human acetyl-CoA carboxylase 2 molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.

Yin Calkin AC, Tontonoz P (2010) Liver x receptor signaling pathways and atherosclerosis. Arterioscler Thromb Vasc Biol 30(8):1513–1518 Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J (2011) Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. e1075 Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF (2005) “New” hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis.

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Hepatic De Novo Lipogenesis and Regulation of Metabolism by James M. Ntambi


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