Read e-book online Handbook of Anticancer Pharmacokinetics and Pharmacodynamics PDF

By Michelle A. Rudek, Cindy H. Chau, William D. Figg, Howard L. McLeod

ISBN-10: 1588291774

ISBN-13: 9781588291776

Best investigators synthesize the whole laboratory and scientific means of constructing anticancer medicinal drugs to create a unmarried quintessential reference that covers all of the steps from the identity of cancer-specific pursuits to section III scientific trials. those specialist authors supply their most sensible counsel on a large choice of concerns, together with medical trial layout, preclinical screening, and the improvement and validation of bioanalytic tools. The chapters on picking brokers to check in section III trials and on trial layout for the approval of recent anticancer brokers supply a distinct roadmap for relocating an agent to NDA submission.

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Blood 1981; 58:1203. 14. Kaye SB. Gemcitabine: current status of phase I and II trials. J Clin Oncol 1994; 12:1527. 15. Schmiegelow K, Bretton-Myer U. 6-Mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high dose methotrexate in children with acute lymphoblastic leukaemia. Leukaemia 2001; 15:74–79. Chapter 1 / Molecular Targets 19 16. Casseileth PA, Lych E, Hines JD, et al. Varying intensity of postremission therapy of acute myeloid leukaemia. Blood 1992; 79:1924.

Scoring a bull’s-eye against cancer genome targets. Curr Opin Pharmacol 2001; 1: 342–352. 6. Futreal PA, Kasprzyk A, Birney E, et al. Cancer and genomics. Nature 2001; 409:850–852. 7. Clarke PA. Pole R, Wooster R, et al. Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential. Biochem Pharmacol 2001; 62:1311–1336. 8. Workman P, Garrett MD. Discovering novel chemotherapeutic drug targets for the third millennium. Eur J Cancer 1999; 35:2010–2030.

Rock KL, Gramm C, Rothstein L, et al. Inhibitors of proteasome inhibition of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994; 79:761–771. 135. Adams J. Proteasome inhibiton: a novel approach to cance therapy. Trends Mol Med 2002; 8(S):49–54. 136. Goldberg AL, Stein R, Adams J. New insights into proteasome function: from archaebacteria to drug dvelopment. Chem Biol 1995; 2:503–508. 137. An B, Goldfarb RH, Siman R, Dou QP. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin dependant kinase inhibitor p27 and induces apoptosis in transformed, but not normal human fibroblasts.

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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (Cancer Drug Discovery and Development) by Michelle A. Rudek, Cindy H. Chau, William D. Figg, Howard L. McLeod


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