Enantioselective Synthesis of Beta-Amino Acids by Eusebio Juaristi, Vadim A. Soloshonok PDF

By Eusebio Juaristi, Vadim A. Soloshonok

ISBN-10: 0471467383

ISBN-13: 9780471467380

Covers all points of the synthesis of ?-amino acids

As evidenced by way of an exponential elevate within the literature released at the topic, curiosity in ?-amino acids has grown during the last a number of years. With significant pharmaceutical functions, those amino acids are actually studied throughout a number of traces of analysis, together with combinatorial chemistry, medicinal chemistry, molecular layout, proteomics, and others.

This moment version of Enantioselective Synthesis of ?-Amino Acids updates experiences integrated within the First version whereas additionally protecting new advancements when you consider that its book. The publication offers unique discussions of crucial tools for the synthesis of ?-amino acids. ordinarily, the lead chemist who initially constructed a style offers an authoritative description of it.

In addition, Enantioselective Synthesis of ?-Amino Acids, moment Edition:
* good points introductory overviews at the structural kinds of proper ?-amino acid pursuits and salient ?-amino acids found in ordinary products
* Dedicates numerous chapters to advances within the synthesis of oligomers from ?-amino acids
* contains normal and functional approaches for the coaching of ?-amino acids in each one chapter
* Discusses crucial equipment which were lately built for the uneven synthesis of cyclic and open-chain ?-amino acids
* encompasses a document at the education of libraries of enantiopure ?-amino acids utilizing combinatorial approaches

The simply ebook of its variety to be had this day, Enantioselective Synthesis of ?-Amino Acids, moment version bargains upper-level scholars and execs an important source for pharmaceutical improvement, medicinal chemistry, and biochemistry.

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Am. Chem. , 1998, 120, 625. 72. Kawahata, N. ; Goodman, M. , 1999, 40, 2271. 73. Axten, J. ; Kung, H. ; Winkler, J. D. J. Org. , 1998, 63, 9628. 74. Hoekstra, W. ; Maryanoff, B. ; Cohen, J. ; Costanzo, M. ; Damiano, B. ; Haertlein, B. ; Harris, B. ; Kauffman, J. ; Keane, P. ; McConsey, D. ; Villani, F. ; Yabut, S. C. Bioorg. Med. Chem. , 1996, 6, 2371. 75. ; Furstoss, R. J. Org. , 1997, 62, 5215. 76. ; Tian, G. ; Kim, D. H. J. Org. , 2001, 66, 3696. 2,3 Therefore, these compounds are often characterized by potent biological and physiological activities4 that are often crucially based on their b-amino acid substructures.

Broderick, T. ; Higby, N. ; Martin, L. ; Anders, R. J. Circulation, 1997, 96, 1117. ; Bouchet, P. , 1994, 35, 9239. de Silva, E. ; Williams, D. ; Andersen, R. ; Holmes, C. F. ; Allen, T. M. , 1992, 33, 1992. ; Dekker, K. ; Huang, L. ; Kojima, Y. J. , 2001, 54, 1060. ; Rinehart, K. ; Dahlem, A. ; Beasley, V. ; Carmichael, W. N. , 1989, 30, 4349. Lurain, A. ; Walsh, P. J. J. Am. Chem. , 2003, 125, 10677. ; Saha-Mo¨ller, C. R. J. Am. Chem. , 2002, 124, 12938. Umezawa, H. Bleomycin: Current Status and New Developments, Academic, New York, 1978.

In those cases the structures are presented according to the experimental data. Ambiguities are mentioned in the corresponding figures. Peptide bonds in chemical structures are drawn regardless to their trans (or cis) amide configuration. 2 NATURAL PRODUCTS CONTAINING b-AMINO ACIDS RELATED TO PROTEINOGENIC a-AMINO ACIDS So far, eight b-amino acids that are directly derived from a corresponding proteinogenic a-amino acid have been discovered in nature either in free form or as a part of a larger molecule: b-alanine (1), b-leucine (2), b-lysine (3), b-arginine (4), b-glutamate (5), b-glutamine (6), b-phenylalanine (7), and b-tyrosine (8) (Fig.

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Enantioselective Synthesis of Beta-Amino Acids by Eusebio Juaristi, Vadim A. Soloshonok

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