Design and Manufacture of Pharmaceutical Tablets - download pdf or read online

By Reynir Eyjolfsson

ISBN-10: 0128021829

ISBN-13: 9780128021828

Design and Manufacture of Pharmaceutical Tablets bargains actual international options and results of formula and processing demanding situations of pharmaceutical capsules. This e-book comprises a variety of useful examples relating to real formulations which were tested and advertised and covers very important information within the components of balance, dissolution, bioavailibity and processing. It presents very important historical past and theoretical details on layout and production and features a complete part devoted to layout experimental method and statistics. furthermore, this ebook bargains a a basic dialogue of excipients utilized in right pill layout besides sensible examples relating to excipients. Drug improvement scientists in and academia, in addition to scholars within the pharmaceutical sciences will vastly enjoy the sensible wisdom and case examples supplied all through this book.

  • Incorporates very important mathematical versions and computational applications
  • Includes particular content material on crucial composite layout and augmented simplex lattice
  • Provides history on very important layout rules with emphasis on quality-based layout (QBD) of pharmaceutical dosage forms

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Read e-book online Design and Manufacture of Pharmaceutical Tablets PDF

Layout and Manufacture of Pharmaceutical capsules deals actual international strategies and results of formula and processing demanding situations of pharmaceutical drugs. This ebook comprises quite a few functional examples regarding genuine formulations which were proven and advertised and covers very important facts within the parts of balance, dissolution, bioavailibity and processing.

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Extra resources for Design and Manufacture of Pharmaceutical Tablets

Sample text

1 Properties of active pharmaceutical ingredient White or almost white, crystalline powder. Sparingly soluble in water, freely soluble in methanol. Very unstable in solid dosage forms if no precautions are taken. Main degradants are hydrolysis (HYD) and cyclization (CYC) products. Batches with mean particle sizes, D[4,3], from 6 to 22 mm (laser light diffraction, dispersion Tegiloxan 3 + 10 s ultrasound) have been used. 2 Design Many drugs of this chemical group have been stabilized in tablets with alkaline excipients that defend against formation of CYC products, and by keeping moisture in the tablets low in order to minimize degradation via the HYD pathway.

Pharmaceutical dosage forms: tablets. Unit operations and mechanical properties, vol. 1. 3rd ed. New York: Informa Healthcare; 2008. In:Augsburger LL, Hoag SW, editors. Pharmaceutical dosage forms: tablets. Rational design and formulation, vol. 2. 3rd ed. New York: Informa Healthcare; 2008. [3] Liltorp K, Kristensen SL, Andresen T. Determination of particle sizes in the pharmaceutical industry. Copenhagen: Books on Demand; 2014. [4] Rowe RC, Sheskey PJ, Cook WG, Fenton ME, editors. Handbook of pharmaceutical excipients.

Flowability of finished granulate was 4 mm (Flodex), which is excellent. Tablet compression was performed with Manesty Betapress using 7 × 19 mm capsule-shaped punches. Tableting speed was 22,000 tablets/h, which proceeded without any problems. The tablets had hardness of about 120 N. 5%. 5% dissolved. The manufacturing method was validated. A bioavailability study showed that the tablets were bioequivalent to the originator’s product. Packaged into Al/PVC blisters and cartons the tablets have a shelf life of 5 years.

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Design and Manufacture of Pharmaceutical Tablets by Reynir Eyjolfsson


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