A entire overview of present considering at the biosynthesis, functionality and evolution of secondary metabolites in animals, crops and microorganisms. Examines the normal context of secondary metabolites as typical items having no noticeable half to play within the generating organism's existence cycle. Covers matters relating to genetic and antibiotic functions.
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Extra info for Ciba Foundation Symposium 171 - Secondary Metabolites: their Function and Evolution
Williams: That is done because along the pathway of photosynthesis, as the electron loses its energy, and as energy goes into smaller quanta, you can drive any reaction going from non-equilibrium towards an equilibrium state, by having a negative AG. I don’t think there’s a problem in principle in getting from one reaction type to the other. References Ellington DE, Szostak JW 1990 In vitro selection of RNA molecules that bind specific ligands. Nature (Lond) 346:818-822 Ellington DE, Szostak JW 1992 Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures.
So I don’t think you can solve the problems by going back into an experiment that we really know nothing about, and cannot conduct. Chater: If you can show effects on intron splicing in vitro, one would expect that those antibiotics should have significant activity in vivo against eukaryotic cells. Is that observed? Davies: I agree with you that this inhibition should take place; in fact, a number of aminoglycosides are toxic to eukaryotic cells. We have additional experiments in progress. Turner: To go back to my earlier point about the type of intron you studied, how widespread are group I introns?
If your hypothesis is correct, it says something interesting about the metabolism of the organisms at that point, namely that they were capable of making aminoglycosides, and therefore there was already an established mechanism of specific carbohydrate synthesis. Cane: They certainly knew how to make ribose! Orgel: That is my point; if they knew how t o make ribose, they had to know how t o make carbohydrates, and therefore to make aminoglycosides; if aminoglycosides were there then, it says a lot about the way the ‘RNA world’ was at the time.
Ciba Foundation Symposium 171 - Secondary Metabolites: their Function and Evolution