Chronic viral hepatitis : diagnosis and therapeutics - download pdf or read online

By Raymond S Koff; George Y Wu

ISBN-10: 0585438862

ISBN-13: 9780585438863

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Example text

However, following discovery of the HCV in 1988, sensitive and specific diagnostic tests to detect HCV infection became available. Widespread application of these tests in blood banks led to a precipitous drop in posttransfusion 30 Carithers hepatitis C. 001% per unit transfused (14). However, it is recommended that individuals exposed to potentially infective blood products before 1992 undergo testing for hepatitis C (15). Currently, the risk of posttransfusion hepatitis B or hepatitis C is quite low (14).

A) Adult-acquired HBV infection. (B) Perinatally acquired HBV infection. Adapted from 44–46. posed as one explanation for the higher frequency of acute liver failure and hepatocellular carcinoma (HCC) in men. In adolescents and adults who acquire HBV, the replicative phase is characterized by a dynamic balance between high levels of HBV replication and expression and a vigorous immune response, which results in hepatic injury (see Fig. 2B). As a result, acute, clinically apparent hepatitis B in a healthy adult culminates, as a rule, in self-limited infection; chronicity is rare (11).

The Sentinel Counties Chronic Non-A, Non-B Hepatitis Study Team. N Engl J Med 1992; 327: 1899–1905. 8. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825–832. 9. Vogt M, Lang T, Frosner G, et al. Prevalence and clinical outcome of hepatitis C infection in children who underwent cardiac surgery before the implementation of blood-donor screening. N Engl J Med 1999; 341: 866–870. 10. Jonas MM. Hepatitis C infection in children.

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Chronic viral hepatitis : diagnosis and therapeutics by Raymond S Koff; George Y Wu


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