By Satinder Ahuja
content material: Chromatography and pharmaceutical research / Satinder Ahuja --
Chromatography and new drug improvement / Satinder Ahuja --
exchange recommendations for research of prescription drugs / John A. Adamovics and Kimberly Shields --
Ruggedness of impurity determinations in prescription drugs : high-performance liquid chromatography research with ultraviolet detection / M.P. Newton, John Mascho, and Randy J. Maddux --
High-performance liquid chromatography in pharmaceutical improvement of antibiotic items / L.J. Lorenz --
fuel chromatography and pharmaceutical analyses / Harold M. McNair and Ketan M. Trivedi --
gasoline chromatography and mass spectrometry of Erythrina alkaloids from the foliage of genetic clones of 3 Erythrina species / Lori D. Payne and Joe P. Foley --
constructing stereoselective high-performance liquid chromatographic assays for pharmacokinetic reports / Irving W. Wainer --
Direct enantiomeric separation and research of a few aromatase inhibitors on cellulose-based chiral desk bound levels / Hassan Y. Aboul-Enein --
Chromatographic research of host-cell protein impurities in prescribed drugs derived from recombinant DNA / Donald O. O'Keefe and Mark L. Will --
Binding proteins in improvement of online postcolumn response detection platforms for liquid chromatography / Minas S. Barbarakis and Leonidas G. Bachas --
choice of a brand new oral cephalosporin in organic fluids : liquid chromatographic, ultraviolet, and mass spectrometric equipment / Hwai-Tzong Pan, Pramila Kumari, and Chin-Chung Lin --
medicines and metabolites in organic fluids : automatic research by means of laboratory robotics / Linda A. Brunner --
Preparative separations of glycerophospholipids via high-performance liquid chromatography / J.V. Amari and P.R. Brown --
Small-molecule pharmaceutical separations through capillary electrophoresis : procedure improvement and manipulation of selectivity / Michael E. Swartz and John VanAntwerp.
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Additional info for Chromatography of Pharmaceuticals. Natural, Synthetic, and Recombinant Products
A parameter expected to have a s i g n i f i c a n t e f f e c t on UV spectra, pH, i n f a c t produced changes i n r e l a t i v e response f a c t o r s which ranged from <5% to 28%. The most s i g n i f i c a n t changes were observed at the wavelengths where the slopes and shapes of the UV curves of the reference and impurity compounds e x h i b i t e d the g r e a t e s t differences. This same trend continued when the solvent strength, i o n i c strength and temperature were modified producing changes i n r e l a t i v e response f a c t o r s up to 15%.
With additional quantities of acetonitrile there is a slight decrease in the retention of the monobactam. The amino acid arginine shows the greatest increase in retentiveness with increasing acetonitrile content while the ^-adrenergic blocking agent, nadolol, shows a moderate increase relative to arginine. This is in contrast to relatively non-polar molecules such as steroids where small changes in acetonitrile concentration lead to disproportionate change in retention time (25). For instance, a 10% acetonitrile concentration does not elute lypophilic steroids, while a 25% eluded them in the solvent front (25).
LC, 1984, 2, 393. 8. Moats, W. A. and Leskinen, L. J. Chromatogr. 1987, 386, 79. 9. Adamovics, J. A. J. Pharm. Biomed. Anal. 1984, 2, 167. 10. Di Bussolo, J. M. and Miller, Ν. T. Seventh International Symposium on HPLC of Proteins, Peptides and Polynucleotides. 1987, Poster 108. 11. Helboe, P. J. Pharm. Biomed. Anal. 1985, 3, 293. 12. Buffar, S. E. and Mazzo, D. J. J. Chromatogr. 1986, 353, 243. 13. ; Mayo, D and Adamovics, J. J. Chromatogr. 1990, 507, 165. 14. The United States Pharmacopeia. , Rockville, MD, 1985, 520.
Chromatography of Pharmaceuticals. Natural, Synthetic, and Recombinant Products by Satinder Ahuja