Cholestatic Liver Disease (Clinical Gastroenterology) by Keith D. Lindor, Jayant A. Talwalkar PDF

By Keith D. Lindor, Jayant A. Talwalkar

ISBN-10: 1588298388

ISBN-13: 9781588298386

Over the last 20 years, there was a gentle bring up in wisdom linked to the medical manifestations of cholestatic liver disorder. in keeping with those medical occasions, this e-book offers helpful and well timed info at the ever-expanding topic of cholestatic liver sickness. It offers medical updates from top specialists which relate to the scientific assessment and administration of cholestatic liver issues.

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Additional info for Cholestatic Liver Disease (Clinical Gastroenterology)

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Gut 1992; 33: 368- 3 71. 46. Garcia Rodriguez L A , Stricker BH , and Zimmerman HJ. Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. Arch Intern Med 1996; 156: 1327- 1 332. 47. Hautekeete ML. Hepatotoxicity of antibiotics. Acta Gastroenterol Belg 1995; 58: 290- 2 96. 84 . Lakehal ,F Dansette PM, Becquemont L , et al. Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes. Chem Res ToxicoI2001; 14: 694-701.

Symptoms present within 1-3 mo after daily ingestion and usually resolve after herb discontinuation (13). There is a report of chaparral-induced fulminant hepatitis that required liver transplantation (74). The mechanism of injury is unknown. 13. Teucrium Chamaedrys (Germander) Germander extract can be found in herbal teas and is used as a diuretic, antipyretic, stimulant, and treatment for gout or abdominal pain. Several cases of germander-induced cholestasis and cholestatic hepatitis have been reported (75).

One study estimated a 380% increase in herbal use between 1190 and 1997 (68). Herbal preparations are not regulated by the Food and Drug Administration, and contrary to popular belief, the use of herbal products can result in serious adverse events (69). Most herbal products are complex mixtures and may be subject to contamination by potentially dangerous substances such as heavy metals, fungal toxins, bacteria, and pesticides (69). The liver is the central site for metabolism of drugs and xenobiotics and, not surprisingly, hepatotoxicity is the most frequent adverse reaction to herbal supplements (70).

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Cholestatic Liver Disease (Clinical Gastroenterology) by Keith D. Lindor, Jayant A. Talwalkar


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