By Gerald Gübitz, Martin G. Schmid
Methods for enantiomer separation are vitally important for controlling synthesis, for checking racemization, for enantiomeric purity keep watch over, and for pharmacokinetic experiences. In Chiral Separations: equipment and Protocols, well-liked specialists from world wide element the chromatographic and electroseparation innovations they've got constructed for chiral separations on an analytical scale. defined in step by step aspect to make sure winning experimental effects, the strategies are offered as both basic tools or as particular functions to substance periods and particular compounds, with emphasis on excessive functionality liquid chromatography and capillary electrophoresis ideas, but in addition together with skinny layer chromotogrphic, fuel chromatographic, and supercritical fluid chromatographic in addition to fresh electrochromotographic suggestions. each one totally demonstrated protocol contains an advent to the primary underlying the tactic, gear and reagent lists, and beneficial notes on troubleshooting and warding off recognized pitfalls.
updated and hugely functional, Chiral Separations: equipment and Protocols may help either beginner and complicated clients not just decide on optimum tools for his or her separation difficulties, but additionally without problems receive profitable results.
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Extra info for Chiral Separations: Methods and Protocols
Electrophoresis 21, 3116–3125. 132. Wistuba, D. and Schurig, V. (2000) Enantiomer separation by capillary electrochromatography on a cyclodextrin-modified monolith. Electrophoresis 21, 3152–3159. 133. Hesse, G. and Hagel, R. (1973) A complete separation of a racemic mixture by elution chromatography on cellulose triacetate. Chromatographia 6, 277–280. 134. , and Yamamoto, K. (1984) Chromatographic resolution. 6. Useful chiral packing materials for high-performance liquidchromatographic resolution-cellulose triacetate and tribenzoate coated on macroporous silica-gel.
2-Phenylcyclohexanone: 10 µL of a 1% methanolic solution applied as a 15-mm streak. c. 2% methanolic solution applied as a 10-mm streak. d. Troeger’s base: 2 µL of a methanolic solution applied as a 15-mm streak. 5. Length of run: 10 cm. 6. 3 h. 7. Detection: UV (254 nm resp. 366 nm). 8. Spectroscopy: λ equals 254 nm (deuterium lamp) or λexc equals 366 nm, λem equals 420 nm (cut-off filter, mercury lamp) (for anthryl derivative) (see Notes 1 and 2). 3. 1. Chromatographic Conditions (According to Weinstein ) 1.
109. , and Lin, B. (2000) Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins. J. Chromatogr. A 875, 135–161. 110. Chankvetadze, B. (1997) Separation selectivity in chiral capillary electrophoresis with charged selectors. J. Chromatogr. A 792, 269–295. 111. , De Zeeuw, R. , De Jong, G. , and Ensing, K. (2000) Recent innovations in the use of charged cyclodextrins in capillary electrophoresis for chiral separations in pharmaceutical analysis. Electrophoresis 21, 3220–3239.
Chiral Separations: Methods and Protocols by Gerald Gübitz, Martin G. Schmid