Read e-book online Burger's Medicinal Chemistry and Drug Discovery, Vol. 2: PDF

By Donald J. Abraham (ed.)

ISBN-10: 0471370282

ISBN-13: 9780471370284

This new quantity comprises severe new chapters on Combinational Chemistry and a number of Parallel Synthesis, excessive Throughput Pharmacology, and Retrometabolism-Based Drug layout and focusing on.

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Roughton, Q. Zhao, J. C. Reader, M. Orlowski, B. Jacob-Samuel, and C. D. Carroll, J. Comb. , 2, 716-731 (2000). 74. D. L. Boger, J. K. Lee, J. Goldberg, and Q. Jin, J. Org. , 65, 1467 (2000). 75. M. B. Andrus, T. M. Turner, Z. E. Sauna, and S. V. Ambudkar, J. Org. , 65, 4973 (2000). 76. A. Gopalsamy and H. Yang, J. Comb. , 2, 378 (2000). 77. J. S. Lazo and P. Wipf, J. Pharmacol. Exp. , 293, 705 (2000). 78. B. Walker, J. F. Lynas, M. A. Meighan, and D. Bromme, Biochem. Biophys. Res. , 275,401 (2000).

Kovacs, and A. Furka, Biorg. Med. Chem. , 3,413 (1993). 69. R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, and J. H. Cuervo, Nature, 354,84 (1991). 70. A. Furka, F. Sebestyen, M. Asgedom, and G. Dibo, Int. J. Pept. 37,487 (1991). 71. K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, and R. J. Knapp, Nature, 354,82 (1991). 72. R. A. Houghton, J. R. Appel, S. E. Blondelle, J. H. Cuervo, C. T. Dooley, and C. Pinilla, Biotechniques, 13,412 (1992). 73. R. E.

Keeping track of this is a job for highspeed computers. Many firms have developed their own programs for the data handling, and there are commercial packages that may be useful as well. The best of these have structure drawing capacity also. 7 Patents Patent considerations are complex in combinatorial chemistry. The mass of potential data is hard to compress into a suitable format for this purpose. Commonly, patenting takes place comparatively late in a drug-seeking campaign and so differs little from traditional patenting.

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Burger's Medicinal Chemistry and Drug Discovery, Vol. 2: Drug Discovery and Drug Development by Donald J. Abraham (ed.)

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