Get Biotechnology and biopharmaceuticals : transforming proteins PDF

By Rodney J. Y. Ho

ISBN-10: 111817979X

ISBN-13: 9781118179796

ISBN-10: 1118659988

ISBN-13: 9781118659984

ISBN-10: 1118660374

ISBN-13: 9781118660379

ISBN-10: 1118660404

ISBN-13: 9781118660409

ISBN-10: 111866048X

ISBN-13: 9781118660485

Biotechnology and Biopharmaceuticals: reworking Proteins and Genes into medicinal drugs, moment Edition addresses the pivotal matters when it comes to translational technological know-how, together with preclinical and scientific drug improvement, regulatory technology, pharmaco-economics and cost-effectiveness issues. the hot variation additionally presents an replace on new proteins and genetic drugs, the translational and built-in sciences that proceed to gas the techniques in drugs, in addition to the recent components of healing improvement together with melanoma vaccines, stem phone therapeutics, and cell-based treatments.

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Extra resources for Biotechnology and biopharmaceuticals : transforming proteins and genes into drugs

Sample text

The drug industry also spends several billion dollars each year on pharmaceutical research to transform novel chemicals and biologics into medicines that are safe and effective for human use. 5 billion, according to the Pharmaceutical Manufacturers Association. S. market, all information is rigorously scrutinized by the Food and Drug Administration (FDA). Independent experts are recruited to assist the FDA in drug evaluation. Whether a drug candidate is a protein, nucleic acid, or small molecule manufactured in the United States or abroad, the same regulations apply.

In fact, the word biotechnology can be traced back to the 1919 writing of Kark Erely in his 84-page publication entitled, “Biotechnologie der Fleisch-, Fett- und Milcherzeugung im landwirtschafttichen Gross-betrieb” (Bud 1989). The coining of the term biotechnologie or “biotechnology” by Erely was likely intended to describe the interaction of biology with technology, thus essentially implying inclusion of all biological and related technologies in product t­rans­formation. Today, the therapeutic products of b ­ io­technologies, which are referred to as biologics or biopharmaceuticals, are central in providing hope and in making advances for treating human diseases ranging from infections, diabetes, and immune disorders to ­cancers.

For example, insulin, which is used to treat diabetes, has several variants that are approved for human use. 4). 3). Yet, both pork and beef insulins have been used successfully to treat diabetes. Although trade names may differ, all the insulins, including those that are modified to produce more desirable pharmacokinetic and disposition profiles, such as insulin-lispro, insulin-glargine, insulin-glulisine, and insulin-aspart, are still known as insulins by physicians and researchers alike. All of these variants of insulin are used for the same treatment indication—to control blood glucose—and are efficacious as long as the dose and dosing frequency are determined on a product-byproduct basis.

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Biotechnology and biopharmaceuticals : transforming proteins and genes into drugs by Rodney J. Y. Ho

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