Download e-book for iPad: Bioreactors : animal cell culture control for bioprocess by Goutam Saha, Alok Barua, Satyabroto Sinha

By Goutam Saha, Alok Barua, Satyabroto Sinha

ISBN-10: 1498736017

ISBN-13: 9781498736015

Bioreactors: Animal mobilephone tradition keep watch over for Bioprocess Engineering offers the layout, fabrication, and keep watch over of a brand new kind of bioreactor intended in particular for animal telephone line tradition. the recent bioreactor, referred to as the "see-saw bioreactor," is perfect for the expansion of cells with a delicate membrane. The see-saw bioreactor derives its identify from its precept of operation within which liquid columns in both limb of the reactor alternately pass up and down. The operating quantity of the reactor is small, to inside of 15 L. even if, it may possibly simply be scaled up for big construction in quantity of telephone mass within the drug and pharmaceutical industries.

The authors describe the primary of operation of the see-saw bioreactor and the way to instantly keep watch over the bioprocess. They talk about assorted regulate concepts in addition to the thorough experimental learn they performed in this prototype bioreactor within which they utilized a time hold up keep watch over for yield maximization.

To provide you with a whole realizing of the layout and improvement of the see-saw bioreactor, the authors hide the mathematical version they use to explain the kinetics of fermentation, the genetic algorithms used for deriving the optimum time trajectories of the bioprocess variables, and the corresponding regulate inputs for maximizing the product yield. One bankruptcy is dedicated to the applying of time hold up keep an eye on. Following an outline of the bioreactor’s operating setup within the laboratory, the authors sum up their research and outline the longer term scope of labor when it comes to layout, keep watch over, and software program sensors.

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Extra info for Bioreactors : animal cell culture control for bioprocess engineering

Example text

Ii. ” • Step 12: Control matrix = new control matrix. • Step 13: Generation = generation + 1. Replace the value of the generation in step 5 by this value. • Step 14: If (generation ≤ 5), go to step 5. Else go to step 15. • Step 15: Find the fitness value for the fifth generation. • Step16: Set average value = 99999. • Step17: Define error = average value − best fitness value Replace the magnitude of error in step 3 by this value. • Step 18: Calculate the average of the fitness values of five generations.

5 Theoretical and actual dissolved oxygen profiles for time period of oscillation = 35 s. 1 Theoretical and actual KL values Exp. no. 3 displays the actual and theoretical dissolved oxygen profiles in the bioreactor when the time period of oscillation is 20 s. This figure shows that the actual dissolved oxygen concentration in the bioreactor is higher than that of the theoretical one. The discrepancy may be explained as follows: • In the theoretical expression, it was assumed that there is no turbulence in the flat surface of the reactor, but some turbulence was present in the liquid medium due to oscillation.

Simul ation of bioprocess and de velopment of BIPROSIM Start Choose any bioreactor Run the program for op-mode 10 and display the op-mode that will produce maximum and minimum products no Choose any op-mode Choose any product yes Is op-mode 9 or 10? Choose any state of interest Is op-mode 9? no yes Solve the model equations for standard value of parameters and known control input values Refresh the time-varying model parameters using estimation algorithms yes Run the program for op-mode 9 and display the time profile of all states Work real time?

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Bioreactors : animal cell culture control for bioprocess engineering by Goutam Saha, Alok Barua, Satyabroto Sinha

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