Read e-book online Bacterial Pili: Structure, Synthesis and Role in Disease PDF

By M.A. Barocchi, J.L. Telford

ISBN-10: 1780642555

ISBN-13: 9781780642550

Bacterial pili play vital roles as environmental sensors, in host colonization and in biofilm formation, allowing micro organism to engage with the surroundings, with surfaces and with different micro organism and host cells. such a lot micro organism, either Gram confident and Gram detrimental, and just about all bacterial pathogens, are piliated. This booklet discusses the synthesis, constitution, evolution, functionality and function in pathogenesis of those advanced constructions, and their foundation for vaccine improvement and therapeutics for Streptococcus pathogens. it truly is a useful source for researchers and scholars of clinical microbiology.

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These pili are typically ~9 nm and flexible, range in length up to 1 micron, and dynamically extend and retract (Fig. 2A). The P-type pili by contrast are thicker (9–11 nm), more rigid, and much shorter than F-pili, although length measurements are complicated by the fact that isolated pili are typically broken (Fig. , 1980, Bradley, 1980; Paranchych and Frost, 1988). A third type of pilus-based transfer system that also has been extensively characterized is encoded by the IncI plasmids, as represented by Pseudomonas aeruginosa plasmid R64.

The P- and F-type systems thus share a common ancestry and VirB-mediated architectural and functional features. The F-type systems, however, also are more complex than P-type systems by virtue of having acquired additional novel domains and protein subassemblies during evolution (Fig. 3C). These systems, for example, code for an outer membrane protein designated TraN. TraN family proteins are large (~600–1200 residues) cysteine-rich proteins thought to function as adhesins for formation of stable donor–recipient cell mating pairs.

M. (2004) An active type IV secretion system encoded by the F plasmid sensitizes Escherichia coli to bile salts. Journal of Bacteriology 186, 5202–5209. E. (1980) Morphological and serological relationships of conjugative pili. Plasmid 4, 155– 169. E. R. (1980) Specification of surface mating systems among conjugative drug resistance plasmids in Escherichia coli K-12. Journal of Bacteriology 143, 1466–1470. C. Jr (1971) The properties of sex pili, the viral nature of ‘conjugal’ genetic transfer systems, and some possible approaches to the control of bacterial drug resistance.

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Bacterial Pili: Structure, Synthesis and Role in Disease by M.A. Barocchi, J.L. Telford

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