By Syed Z. Ali MD, Yener S. Erozan MD, Ralph H. Hruban MD
Medical and radiologic examinations can't reliably distinguish benign or inflammatory pancreatic disorder from carcinoma. The elevated use of pancreatic fantastic needle aspiration (FNA) besides advances in imaging concepts and the creation of endoscopic ultrasound suggestions have ended in a lot better detection and popularity of pancreatic lots. accordingly, pancreatic cytopathology is critical to actual pre-operative prognosis, but it's a demanding diagnostic quarter with various strength pitfalls and ???„????look-alike???„???? lesions. Skillful attractiveness and an understanding of the constraints of the approach are crucial in averting misdiagnosis of those risky lesions. Atlas of Pancreatic Cytopathology with Histopathologic Correlations fills a void in present pathology literature. With 450 high-resolution photographs, together with photos of histopathologic and radiologic good points, this sensible atlas provides an built-in method of diagnostic cytopathology that might aid doctor cytopathologists, cytotechnologists, and pathologists stay away from capability pitfalls and ""look-alike"" lesions. Written through well-known specialists within the box, the huge high-resolution colour photos of the attribute positive factors of pancreatic affliction are provided with specific descriptions that hide vintage gains, diagnostic clues, and power pitfalls. Atlas of Pancreatic Cytopathology with Histopathologic Correlations is a necessary source for the professional cytopathologist, common and surgical pathologists, pathology trainees, and cytotechnologists.
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Additional info for Atlas of Pancreatic Cytopathology with Histopathologic Correlations
Enlarged nuclei with micronucleoli and scattered neutrophils are a common finding in chronic pancreatitis. The mild cytologic atypia can be ascribed to reactive cellular changes secondary to prolonged inflammation of the pancreas. It is imperative to have a higher threshold for “atypical” or neoplastic diagnosis when dealing with cases of chronic pancreatitis. Note the clean smear background. 10 — Chronic pancreatitis. Cells with significant epithelial atypia are present. They have disorganized and enlarged nuclei, which appear hyperchromatic, forming three-dimensional structures.
Chapter 2: Radiologic Characteristics of Pancreatic Disease 21 Selected Cases Illustrating Salient Radiologic Characteristics Case 6 Infiltrating adenocarcinoma arising in an IPMN with markedly dilated pancreatic duct (84-year-old woman with painless jaundice and pancreatic abnormality). (A) Venous phase contrastenhanced axial CT of the upper abdomen showing a cystic mass with a small enhancing nodule lateral to the common duct in the uncinate process of the pancreas (arrows). Note the common bile duct stent (arrowhead) and the dilated pancreatic duct.
Conspicuity of small functioning PEN may be greatest in the arterial phase, although some PENs are better seen in the venous phase. Small PENs appear as homogeneous masses hyperattenuating compared to the normal pancreas. Large PENs tend to outgrow their blood supply and have a more heterogeneous pattern of enhancement. Central areas of necrosis and calcifications are not uncommon. Pancreatic Lymphoma Although lymphoma—predominantly the nonHodgkin B-cell type—can involve peripancreatic lymph nodes and secondarily spread to the pancreas, primary lymphoma of the pancreas is uncommon.
Atlas of Pancreatic Cytopathology with Histopathologic Correlations by Syed Z. Ali MD, Yener S. Erozan MD, Ralph H. Hruban MD