Download PDF by Wilson Golder N.: AHFS Drug Information 2004

By Wilson Golder N.

ISBN-10: 0071375783

ISBN-13: 9780071375788

Supplies clinical scholars 500 questions, solutions, and causes to arrange for the biochemistry and genetics sections of the USMLE Step 1. the hot variation comprises many new questions within the two-step medical structure to simulate the USMLE Step 1.

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D. e. qxd 18 11/14/01 10:36 AM Page 18 Biochemistry and Genetics 27. Which of the following statements correctly describes the recombinant DNA tool known as plasmids? a. b. c. d. e. They are found more commonly in viruses than in bacteria They are single-stranded circles They sometimes enhance bacterial susceptibility to antibiotics They sometimes enhance bacterial resistance to antibiotics They are too small to be useful as vectors for the cloning of mammalian DNA segments 28. Which of the following molecules is found in a nucleoside?

The answer is e. (Murray, pp 412–434. Scriver, pp 677–704. Sack, pp 3–29. ) Xeroderma pigmentosum (278700) appears to be due to the inability of an excision-repair system to remove thymine dimers, which are formed on exposure of DNA to ultraviolet radiation. This results in a deficiency in the ability to repair the damaged DNA. Mutagenesis by this mechanism is presumably the basis for the multiple neoplasms that occur in patients who have this disease. 21. The answer is e. (Murray, pp 412–434. Scriver, pp 3–45.

B. c. d. e. Stop codons Peptidyl transferase Release factors Dissociation of ribosomes UAA 60. The function of signal recognition particles is to a. b. c. d. e. Cleave signal sequences Detect cytosolic proteins Direct the signal sequences to ribosomes Bind ribosomes to endoplasmic reticulum Bind mRNA to ribosomes 61. Which of the following statements about ribosomes is true? a. They are an integral part of transcription b. They are found both free in the cytoplasm and bound to membranes c. They are bound together so tightly they cannot dissociate under physiologic conditions d.

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AHFS Drug Information 2004 by Wilson Golder N.

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