By Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni
This publication bargains up to date and entire insurance of the prognosis and treatment of adenocarcinoma of the esophagogastric junction (EGJ). As is acceptable within the period of multidisciplinary and multimodal therapy, the contributions of the entire numerous experts concerned cooperatively within the therapy of EGJ melanoma are completely defined. specified consciousness is additionally paid to the importance of preneoplastic lesions, akin to Barrett esophagus. the ultimate a part of the ebook represents a surgical atlas documenting the thoughts utilized in the EGJ quarter, with incredible colour pictures and stepwise description of systems. opposed to the heritage of the speedily expanding occurrence in EGJ melanoma, specifically obvious in Western international locations, there's a desire for better uniformity in administration thoughts, which at the moment range considerably internationally. This e-book presents acceptable tips that might support all practitioners interested by the prognosis and therapy of EGJ cancers, together with surgeons, oncologists, and radiotherapists.
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Extra resources for Adenocarcinoma of the Esophagogastric Junction: From Barrett's Esophagus to Cancer
As per recently pub- chronous neoplasia. In the absence of visible lished British guidelines , in patients treated lesions, ablative therapy is the treatment of for HGD, endoscopic follow-up is recommended choice. In view of risk of recurrence, patients every 3 months for 1 year and yearly thereafter. need to be on ongoing surveillance with treatThis should include biopsies at the cardia and ment of recurrences endoscopically. Due to the lack of head-to-head randomized within the previous extent of the Barrett’s epithelium.
In recent longitudinal studies on the incidence of EA, HGD was considered an end point “per se,” making no difference vis-à-vis invasive adenocarcinoma. A reliable diagnosis of HGD prompts more aggressive therapies with curative intent, such as mucosectomy, esophageal mucosa resection, radiofrequency ablation, or even esophageal resection , if the patient is fit for surgery and endoscopic therapies are not feasible. Hvid-Jensen F, Pedersen L, Drews AM et al (2011) Incidence of adenocarcinoma among patients with Barrett’s esophagus.
Berenson MM, Johnson TD, Markowitz NR et al (1993) Restoration of squamous mucosa after ablation of Barrett’s esophageal epithelium. Pech O, Behrens A, May A et al (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high- grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57:1200–1206 3. Bergman JJGHM, Fockens P (2006) Ablating Barrett’s metaplastic epithelium: are the techniques ready for clinical use?
Adenocarcinoma of the Esophagogastric Junction: From Barrett's Esophagus to Cancer by Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni